11/19/2023 0 Comments A flutter ablation success rate![]() Finally, we conclude with the major knowledge gaps in ablation of AF.Ītrial fibrillation ablation: Approaches, efficacy, and safety We consider the interrelationship between AF and heart failure (HF) and the effect of ablation on AF burden and heart function. We then review clinical trials that addressed ablation to prevent recurrences of AF after failure of medical therapy, ablation as the initial approach to treatment of AF, the effect of ablation on QOL, and the results of clinical trials that examined clinical outcomes after ablation. We discuss the definition of a successful procedure, options for monitoring of recurrences, the definition of AF burden and how to assess it, techniques used for ablation, complications, and expected success rates. The purpose of this review is to summarize the results of the major clinical trials of AF ablation, examine what we have learned, and understand what questions remain unanswered. An important additional goal is to improve adverse clinical outcomes in patients with AF. The primary goal of AF ablation is to decrease or eliminate recurrences of AF, particularly those that are symptomatic and adversely affect quality of life (QOL). Pulmonary vein isolation (PVI) using either radiofrequency or cryoballoon ablation has since emerged as a safe and effective treatment modality in patients with AF, although patients with more advanced stages of AF often require adjunctive lesions in addition to PVI. Haïssaguerre and colleagues 1 first identified pulmonary veins to be the main trigger source for AF. Antiarrhythmic drugs (AADs) can suppress or delay recurrences of AF, but their efficacy is less than optimal in many patients. In this review, we summarize the major clinical trials involving ablation discuss the strengths, weakness, and clinical implications of these trials and highlight the knowledge gaps in our current understanding of AF ablation for future clinical studies.Ītrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major source of morbidity and mortality. These trials clarify the durability of ablation in arrhythmia control, clarify quality-of-life improvement, and identify patient populations in whom ablation may be expected to improve clinical outcomes. Randomized clinical trials have evaluated ablation in several patient populations, including symptomatic patients as first-line or second-line therapy, asymptomatic patients, and patients with heart failure. Besides arrhythmia control, improvement in quality of life and clinical outcomes are also desirable goals with AF treatment. Ablation is effective at reducing recurrent atrial arrhythmias and also in the reduction of AF burden. Radiofrequency and cryoballoon catheter ablation are therapeutic options in addition to antiarrhythmic drug therapy for the treatment of AF. Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in clinical practice.
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