11/21/2023 0 Comments Tad cooper referenceInterestingly, a comparison of CV+ and CV− subgroups showed that this mediating relationship was only evident in older adults with at least one CV risk factor. The indirect pathway from arterial pulsatility to working memory performance via both MD and RaD measures was significant in this group. In older adults, higher MD and RaD were associated with increased arterial pulsatility and poorer working memory performance. Neither the whole group analysis nor the younger adult group showed an association between measures of arterial pulsatility, global white matter microstructural organization, and cognition. Cognitive ability was assessed using global cognitive functioning (MoCA) and a measure of working memory. Arterial pulsatility was measured using cardiac-gated phase-contrast flow quantification sequence and three indexes of whole-brain white matter microstructural organization were derived from diffusion-weighted imaging (DWI). The latter were further subdivided into two subgroups with (CV+, n = 25) and without (CV−, n = 67) cardiovascular risk factors. One hundred and eighty-nine adults were divided into a younger adult (50 years, n = 92). ![]() This study examines the relationship among arterial pulsatility, white matter microstructural organization, and cognitive ability in a healthy adult lifespan sample. In people with cardiovascular risk factors, increased cerebral arterial pulsatility is associated with poorer white matter microstructural organization and cognitive functioning. 7Department and Institute of Public health, National Cheng Kung University, Tainan, TaiwanĪging is associated with an increased prevalence of vascular health conditions that are linked to a disruption in the cerebral vasculature and white matter microstructural organization.6Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.5Department of Psychology, National Cheng Kung University, Tainan, Taiwan.4Hunter Medical Research Institute, Newcastle, NSW, Australia.3Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia. ![]() 2Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science, University of Newcastle, Newcastle, NSW, Australia.1Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |